A Systematic Review of Stakeholder Views on the Societal Implications of Revolutionary Reproductive Technology
Artificial gametes represent one of the most transformative developments in reproductive medicine, with the potential to redefine human reproduction and family structures 1 . This systematic review examines stakeholder perspectives on the clinical application of this groundbreaking technology.
of couples worldwide affected by infertility
Key ethical objectives identified
Stakeholder perspectives analyzed
This systematic review employed rigorous methodology to analyze stakeholder views across multiple dimensions of artificial gamete technology.
Comprehensive database search including PubMed, Scopus, and Web of Science using predefined search terms related to artificial gametes and stakeholder perspectives 1 .
Inclusion criteria focused on empirical studies, ethical analyses, and policy documents discussing stakeholder views on clinical applications of artificial gametes.
Systematic extraction of data regarding stakeholder types, methodological approaches, and key findings using standardized forms.
Identification of recurring themes and ethical considerations across different stakeholder groups using qualitative analysis methods.
Focus on safety, efficacy, and clinical implementation challenges. Emphasize need for rigorous testing and established protocols 1 .
Concerned with moral boundaries, societal implications, and justice considerations in access to reproductive technologies.
Infertile individuals and couples expressing both hope for biological parenthood and concerns about safety and social acceptance 1 .
Focused on regulatory frameworks, public health implications, and international harmonization of guidelines 1 .
| Application | Potential Benefits | Stakeholder Support Level |
|---|---|---|
| Infertility Treatment | Addresses severe male and female infertility causes |
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| Same-Sex Couples | Enables genetic relation to both partners |
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| Fertility Preservation | Helps prepubertal cancer patients |
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| Genetic Disease Prevention | Combined with gene editing to eliminate inherited disorders |
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| Post-menopausal Reproduction | Extends reproductive timeline |
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"The desire or need to have genetic offspring of one's own does not warrant the investment of research resources into these technologies without careful consideration of broader implications."
Concerns about genetic stability, long-term health consequences, and variable efficiency in current research 1 .
Questions about appropriate applications and potential misuse of reproductive technology.
Most countries lack specific regulations governing artificial gametes, creating legal uncertainty 1 .
Risk of technology becoming a luxury item, widening existing social inequalities 1 .
Unknown psychological and social implications for children born through these technologies.
The clinical application of artificial gametes presents both unprecedented opportunities and significant ethical challenges. A balanced approach that prioritizes safety, equity, and inclusive dialogue is essential for responsible development of this transformative technology 1 .