Research Articles
Computational Modeling of Endometrial Dynamics: From Digital Twins to Clinical Translation
This article provides a comprehensive overview of the rapidly evolving field of computational modeling of the endometrium, a critical frontier in women's health research. We explore the foundational mathematical principles, from phenomenological models capturing hormonal regulation to sophisticated quantitative systems pharmacology (QSP) frameworks. The review details the application of diverse methodologies, including machine learning for diagnostic prediction, spatial eco-structural models of the tumor microenvironment, and agent-based simulations. We critically examine the challenges of model validation and optimization, highlighting the synergistic role of 3D organoids as biological validation platforms and the use of AI for refining model parameters. Finally, we present a comparative analysis of model types—from fractional calculus for capturing treatment memory effects to optimal control theory for designing personalized therapy regimens. This synthesis is tailored for researchers, scientists, and drug development professionals seeking to leverage computational power to decode endometrial biology, accelerate therapeutic discovery, and pave the way for personalized medicine in conditions like endometriosis, endometrial cancer, and infertility.
Hormonal Control of Endometrial Gene Expression: From Molecular Mechanisms to Clinical Translation
This comprehensive review synthesizes current knowledge on how ovarian steroid hormones estradiol and progesterone orchestrate dynamic gene expression programs in the human endometrium throughout the menstrual cycle. We explore foundational transcriptomic and epigenetic mechanisms, advanced organoid and single-cell methodologies for studying endometrial biology, challenges in biomarker discovery and personalized medicine applications, and validation approaches through genetic mapping and clinical testing. By integrating insights from recent single-cell RNA sequencing, epigenetic analyses, and endometrial receptivity studies, this article provides researchers and drug development professionals with a multifaceted understanding of endometrial gene regulation and its implications for treating infertility and endometrial disorders.
The Human Plastisphere: When Our Bodies Become Home to Microplastics
Explore the groundbreaking discovery of the human plastisphere - how microplastics accumulate, distribute, and interact with our tissues, creating a new biological system within our bodies.
The Mindful Beginning: Mental Health and Development of Children Conceived Through ART
Exploring the mental development and health outcomes of children born through assisted reproductive technologies based on longitudinal research studies.
The Genetic Blueprint: 155 Years of Nucleic Acids Discovery
Explore the fascinating journey of nucleic acids discovery from Miescher's nuclein to modern genomics, celebrating 155 years of genetic research breakthroughs.
Beyond Biology: How a 12th-Century Masterpiece Decodes Menstruation and Postpartum Bleeding
Exploring Fakhr al-Din al-Razi's 12th-century masterpiece Mafatih al-Ghayb and its integrative analysis of menstruation and postpartum bleeding through Islamic law, medicine, and philosophy.
The Last of Their Kind: What Winged Mice Can Teach Us About Extinction
Exploring conservation biology through Tatsuaki Ishiguro's story of the last winged mice and what they reveal about extinction science.
Unlocking the Reproductive Secrets of the Deer Mouse: A Scientific Atlas
A comprehensive physiological and histological atlas of reproduction in the North American deer mouse (Peromyscus maniculatus) - groundbreaking 2025 study findings.
Satellite Tags and Southern Right Whales: Unveiling an Ocean Mystery
How tiny electronic trackers are revolutionizing our understanding of southern right whales, their migratory patterns, and conservation needs.
Navigating Taboos: The Challenges of Teaching Sex Education in Sri Lankan Classrooms
Exploring the cultural and educational challenges faced by male science teachers in Sri Lanka when teaching sexual and reproductive health education.